![]() Prior studies examining the prognostic value of V D/V T have had limitations that prevent the generalizability of their results to subjects eligible for therapeutic clinical trials, including the fact that subjects were studied at only 1 or 2 hospitals. 5, 6Ī pulmonary-specific physiologic variable such as V D/V T, which is strongly associated with mortality, could be useful in assessing the efficacy of new therapies for ARDS in prospective clinical trials. ![]() 2– 8 Moreover, sustained elevation of V D/V T in ARDS has been associated with higher mortality. 1 However, newer evidence indicates that V D/V T is markedly elevated within 24 h of ARDS onset and is significantly elevated in non-survivors. Historically, elevated V D/V T in patients with ARDS was thought to be a late-occurring phenomenon associated with the fibroproliferative stage of injury. ![]() Physiologic dead-space fraction (ratio of dead space to tidal volume ) is the portion of tidal volume that does not participate in gas exchange and therefore consists of expired gas without carbon dioxide.
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